Ataprost  (Synonyms: ONO 41483)

Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm^[1].

Platelet aggregation^[1]

Ataprost 抑制人类和狒狒富血小板血浆 (PRP) 中的血小板聚集，ED₅₀ 分别为 1.91 ng/mL 和 4.38 ng/mL^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ataprost (50-200 μg/kg; p.o.; 单剂量) 通过口服的方式，抑制狒狒血小板聚集的 ED₅₀ 为 87 μg/kg^[1]。
Ataprost (i.v.; 单剂量) 通过静脉注射的方式，抑制狒狒血小板聚集的 ED₅₀ 为 3.2 μg/kg^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

348.48

C₂₁H₃₂O₄

83997-19-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Adaikan PG, et al. Inhibition of platelet aggregation and reversal of vasopressin-induced ECG changes by a carboprostacyclin analogue, ONO 41483, in primates. Prostaglandins Leukot Med. 1982 Sep;9(3):307-20.  [Content Brief]