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  4. ATIC-IN-1

ATIC-IN-1 (compound 14) 是一种靶向氨基咪唑甲酰胺核糖核苷酸转化酶/肌苷一磷酸环化水解酶 ( ATIC ) 二聚化的抑制剂，Ki 值为 685 nM。ATIC 二聚化对其氨基咪唑甲酰胺核糖核苷酸 (AICAR) 转化酶活性至关重要。ATIC-IN-1 通过降低细胞数量和细胞分裂率表现出抗肿瘤活性。

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ATIC-IN-1 Chemical Structure

ATIC-IN-1 Chemical Structure

CAS No. : 1402453-15-9

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ATIC-IN-1 的其他形式现货产品:

Customer Review

Other Forms of ATIC-IN-1:

ATIC-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].

IC50 & Target

Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC)[1]
体外研究
(In Vitro)

ATIC-IN-1（10 μM, 50 μM）是一种特异性抑制剂，在 1 mg/mL 和 10 mg/mL BSA 存在或不存在时，表现出非特异性聚集机制[1]。
ATIC-IN-1（100-500 μM；48 h）抑制 MCF-7 细胞的增殖[1]。
ATIC-IN-1（250 μM；24-72 小时）导致分裂减少而不是导致细胞死亡增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ATIC-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 100 μM, 250 μM, 500 μM
Incubation Time: 0 h, 24 h, 48 h, and 72 h
Result: Reduced the division rate to inhibit MCF-7 proliferation at 250 μM.
分子量

463.53

Formula

C21H33N7O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

ATIC-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATIC-IN-11402453-15-9OthersInhibitorinhibitorinhibit

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目录号：
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