2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. ATM Inhibitor-11

ATM Inhibitor-11 (Compound 1) 是 ATM 的抑制剂，IC500 为 0.32 nM。ATM Inhibitor-11 抑制 KAP1 磷酸化，IC500 为 0.97 nM。ATM Inhibitor-11 在 ICR 小鼠的大脑、心脏和血浆中表现出高暴露度。ATM Inhibitor-11 在 NCI-H441 异种移植小鼠模型中表现出抗肿瘤活性。

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ATM Inhibitor-11 Chemical Structure

ATM Inhibitor-11 Chemical Structure

CAS No. : 2878473-51-7

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ATM Inhibitor-11 相关抗体

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ATM ATR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATM Inhibitor-11 (Compound 1) is an inhibitor for ATM with an IC500 of 0.32 nM. ATM Inhibitor-11 inhibits the KAP1 phosphorylation with an IC500 of 0.97 nM. ATM Inhibitor-11 exhibits high exposure in the brain, heart and plasma of ICR mouse. ATM Inhibitor-11 exhibits anti-tumor efficacy in NCI-H441 xenograft mouse model[1].

IC50 & Target

ATM

0.32 nM (IC50)

分子量

492.59

Formula

C27H33FN6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATM Inhibitor-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATM Inhibitor-112878473-51-7ATM Inhibitor11ATM Inhibitor 11ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedMCF-7ICR mouseNCI-H441C57BL/6 mouseInhibitorinhibitorinhibit

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目录号：
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