2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. ATX inhibitor 18

ATX inhibitor 18 是一种有效的 ATX 抑制剂，IC50 值为 24.2 nM。ATX inhibitor 18 显示出抗增殖活性和抗纤维化活性。ATX inhibitor 18 抑制 TGF-β 介导的心脏纤维化中的胶原蛋白沉积。

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ATX inhibitor 18 Chemical Structure

ATX inhibitor 18 Chemical Structure

CAS No. : 2402772-30-7

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ATX inhibitor 18 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATX inhibitor 18 is a potent ATX inhibitor with an IC50 value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis[1].

IC50 & Target[1]

Autotaxin

24.2 nM (IC50)

体外研究
(In Vitro)

ATX inhibitor 18 (compound 8b) (10 µM; 48 h) 在 CFs、t-HSC/Cl-6 细胞中显示出抗增殖活性[1]。
TX inhibitor 18 (0-4 µM) 具有抗纤维化活性，对 CF、t-HSC/Cl-6 细胞的 IC50 值分别为 0.87 和 1.10 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ATX inhibitor 18 相关抗体:

Cell Viability Assaysup>[1]

Cell Line: CFs, t-HSC/Cl-6 cells
Concentration: 10 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity with inhibitory activity of 81.5% and 79.4% for CFs, t-HSC/Cl-6 cells, respectively.
分子量

459.30

Formula

C21H17Cl2FN6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATX inhibitor 18 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATX inhibitor 182402772-30-7ATX inhibitor18ATX inhibitor-18Phosphodiesterase (PDE)CFst-HSC/Cl-6 cellsantiproliferativeanti-fibrosiscollagenTGF-βInhibitorinhibitorinhibit

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产品名称：
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