2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. Aurora Kinases-IN-2

Aurora Kinases-IN-2 (compound 12Aj) 是一种有效的 Aurora 激酶抑制剂 (Aurora kinases)，对 Aurora A 和 Aurora B 的 IC50 值分别为 90 和 152 nM。Aurora Kinases-IN-2 通过调节细胞周期蛋白 B1 和 cdc2 将细胞周期阻滞在 G2/M 期。Aurora Kinases-IN-2 可用于癌症研究。

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Aurora Kinases-IN-2 Chemical Structure

Aurora Kinases-IN-2 Chemical Structure

CAS No. : 2241914-86-1

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Aurora Kinases-IN-2 相关抗体

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查看 Aurora Kinase 亚型特异性产品:

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Aurora Kinase Aurora A Aurora B Aurora C

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research[1].

IC50 & Target[1]

Aurora A

90 nM (IC50)

Aurora B

152 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
1.34 μM
Compound: 12Aj
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 32035750]
HepG2 IC50
7.3 μM
Compound: 12Aj
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 32035750]
LoVo IC50
1.64 μM
Compound: 12Aj
Antiproliferative activity against human LoVo cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human LoVo cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 32035750]
U-87MG ATCC IC50
11.5 μM
Compound: 12Aj
Antiproliferative activity against human U87 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 32035750]
体外研究
(In Vitro)

Aurora Kinases-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC50 values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aurora Kinases-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 1, 5 and 10 μM
Incubation Time: 24 hours
Result: Decreased the expression level of Aurora A and B, as well as reduced phosphorylation of Aurora A on Thr288 (p-Thr288) and Aurora B on Thr232 (p-Thr232) in a dose-dependent manner.
分子量

435.86

Formula

C22H18ClN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aurora Kinases-IN-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurora Kinases-IN-22241914-86-1Aurora Kinaseanti-tumoraurora kinasepyrazinescell cycleInhibitorinhibitorinhibit

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