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  3. 海洋天然产物 其他类
  4. Avarone

Avarone  (Synonyms: (+)-Avarone)

目录号: HY-135771
产品使用指南

摩尔计算器

Avarone ((+)-Avarone) 是一种可从 Dysidea avara 中分离得到的倍半萜醌。Avarone 具有细胞毒性。Avarone 具有抗白血病活性。

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Avarone Chemical Structure

Avarone Chemical Structure

CAS No. : 55303-99-6

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Avarone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity[1][2].

体外研究
(In Vitro)

Avarone (24, 48, 72 h) 抑制 U937 细胞生长，在 24、48、72 小时的 IC50 值分别为 95.8、52.9、33.5 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Avarone 相关抗体:

Cell Cytotoxicity Assay[2]

Cell Line: L5178Y, Melanoma, Hela, fibroblasts, human gingival cells
Concentration:
Incubation Time:
Result: Showed cytotoxicity for L5178Y, Melanoma, Hela, fibroblasts, human gingival cells with ED50s of 0.62, 26.4, 8.7, 11.3, 76.4 µM, respectively.
体内研究
(In Vivo)

Avarone (10 mg/kg; i.p.; once daily for 5 days) 可延长白血病小鼠的寿命[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-9 months, 32-35 g Male outbred NMIR mice (L5178Y cells)[2]
Dosage: 10 mg/kg
Administration: I.p.; once daily for 5 days
Result: Increased life span over controls by 146% when treatment was begun 1 day after tumor implantation and by 87% when treatment was delayed until day 8.
分子量

312.45

Formula

C21H28O2
CAS 号
结构分类
初始来源

Dysidea avara
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Avarone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avarone55303-99-6(+)-AvaroneOtherscytotoxicityantileukemic activityU937 cellsL5178Y cellsInhibitorinhibitorinhibit

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