2. GPCR/G Protein
  3. Guanylate Cyclase
  4. Avenciguat

Avenciguat  (Synonyms: BI-685509)

目录号: HY-153092
产品使用指南

摩尔计算器

Avenciguat (BI-685509) 是一种口服有效的 sGC 激活剂。Avenciguat 可恢复环磷酸鸟苷 (cGMP) 并改善一氧化氮 (NO) 通路的功能。Avenciguat 可用于慢性肾病 (CKD) 和糖尿病肾病 (DKD) 的研究。

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Avenciguat Chemical Structure

Avenciguat Chemical Structure

CAS No. : 1579514-06-9

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规格 价格 是否有货
1 mg ￥3000
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5 mg 现货 询问价格 & 货期
10 mg 现货 询问价格 & 货期
25 mg 现货 询问价格 & 货期

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Customer Review

Avenciguat 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Avenciguat (BI-685509) is a potent and orally active sGC activator. Avenciguat restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. Avenciguat can be used in research of chronic kidney disease (CKD) and diabetic kidney disease (DKD)[1].

体外研究
(In Vitro)

Avenciguat 在用血红素氧化剂 ODQ (HY-101255) 处理的人和大鼠富含血小板的血浆中增加 cGMP，EC50 值分别为 467 nM 和 304 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Avenciguat 相关抗体:
体内研究
(In Vivo)

Avenciguat (1, 3, 10, 30 mg/kg; p.o.) 与 Enalapril (HY-B0331) 共同给药以剂量依赖性方式降低蛋白尿和肾小球硬化的发生率[1]。
Avenciguat (30 mg/kg; p.o.) 减少大鼠单侧输尿管梗阻 (UUO) 模型中的肾小管间质纤维化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ZSF1 rat model[1]
Dosage: 1, 3, 10, 30 mg/kg; 3 mg/kg (enalapril)
Administration: Oral administration; daily
Result: Reduced proteinuria and incidence of glomerular sclerosis in a dose-dependent manner.
Animal Model: rat UUO model[1]
Dosage: 30 mg/kg
Administration: v
Result: Reduced tubulointerstitial fibrosis in rat UUO model.
Clinical Trial
分子量

582.69

Formula

C34H38N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Avenciguat 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avenciguat1579514-06-9BI-685509BI685509BI 685509Guanylate Cyclasecyclic guanosine monophosphatenitric oxidechronic kidney diseasediabetic kidney diseaseInhibitorinhibitorinhibit

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