2. MAPK/ERK Pathway
  3. Raf MEK
  4. Avutometinib potassium

Avutometinib potassium  (Synonyms: Ro 5126766 potassium; CH5126766 potassium)

目录号: HY-18652A
产品使用指南

摩尔计算器

Avutometinib (CH5126766) (potassium) 是一种 RAF/MEK 钳子，能有效抑制 RAF/MEK 激酶活性，诱导 RAF-MEK 负复合体，阻止 ARAF，BRAF 和 CRAF 对 MEK 的磷酸化。Avutometinib (potassium) 在携带 KRAS 突变的肿瘤细胞系 (包括 PDAC 细胞系) 中显示出抗增殖能力。在 KRAS/p53 胰腺癌小鼠模型中，Avutometinib (potassium) 诱导肿瘤抑制并提高生存率。Avutometinib (potassium) 有望用于低级别浆液性卵巢癌 (LGSOC)，卵巢癌和胰腺导管腺癌 (PDAC) 的研究。

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Avutometinib potassium Chemical Structure

Avutometinib potassium Chemical Structure

CAS No. : 946128-90-1

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Avutometinib potassium 的其他形式现货产品:

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Avutometinib potassium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Avutometinib (CH5126766) (potassium) is a RAF/MEK clamp that potently inhibits RAF/MEK kinase activity and induces dominant negative RAF-MEK complexes preventing phosphorylation of MEK by ARAF, BRAF and CRAF. Avutometinib (potassium) shows anti-proliferative potency across tumor cell lines carrying KRAS mutations including PDAC cell lines. Avutometinib (potassium) induces tumor inhibition and increases survival in a KRAS/p53 pancreatic cancer mouse model. Avutometinib (potassium) is promising for research of low-grade-serous-ovarian-carcinoma (LGSOC), ovarian cancer and pancreatic ductal adenocarcinoma (PDAC)[1][2].

分子量

510.56

Formula

C21H18FKN5O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Avutometinib potassium 相关分类

  • 摩尔计算器

  • 稀释计算器

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avutometinib946128-90-1Ro 5126766CH5126766Ro5126766Ro-5126766CH 5126766CH-5126766RafMEKRaf kinasesMitogen-activated protein kinase kinaseMAPKKMAP2KRAF/MEKARAFBRAFCRAFanti-proliferativetumor inhibitionmouseLGSOCovarian cancerPDACInhibitorinhibitorinhibit

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