1. Neuronal Signaling
  2. Beta-secretase
  3. AZ-4217

AZ-4217 是 β 位淀粉样蛋白前体裂解酶 1 (BACE1) 的抑制剂,在人类 SH-SY5Y 细胞中的 IC50 为 160 pM。AZ-4217 可减少 Tg2576 小鼠模型中的淀粉样蛋白沉积,并用于阿尔茨海默病研究。

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AZ-4217 Chemical Structure

AZ-4217 Chemical Structure

CAS No. : 1383846-83-0

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生物活性

AZ-4217 is an inhibitor for β-site amyloid precursor protein cleavage enzyme 1 (BACE1), with IC50 of 160 pM in human SH-SY5Y cells. AZ-4217 reduces amyloid deposition in Tg2576 mouse models, and is used for Alzheimer’s Disease research[1].

分子量

476.54

Formula

C30H25FN4O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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AZ-4217
目录号:
HY-18112
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