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  4. AZ11657312

AZ11657312是一种P2X7受体拮抗剂，具有恢复压力排钠的活性。AZ11657312可以显著提高肾髓质灌注，仅在接受血管紧张素II处理的老鼠中有效。AZ11657312通过阻断P2X7R改善组织氧合，特别是在肾脏氧合不足的区域。AZ11657312的使用可以促进钠排泄达到六倍，同时使血压恢复正常。

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AZ11657312 Chemical Structure

AZ11657312 Chemical Structure

CAS No. : 804561-22-6

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AZ11657312 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZ11657312 is a P2X7 receptor antagonist with activity to restore stress natriuresis. AZ11657312 significantly increased renal medullary perfusion, only in mice treated with angiotensin II. AZ11657312 improves tissue oxygenation by blocking P2X7R, especially in areas of the kidney that are underoxygenated. Administration of AZ11657312 increased sodium excretion up to sixfold while normalizing blood pressure[1].

分子量

437.57

Formula

C26H35N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AZ11657312 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ11657312804561-22-6AZ 11657312AZ-11657312OthersInhibitorinhibitorinhibit

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目录号：
HY-122282
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