2. Stem Cell/Wnt
  3. Smo
  4. AZD7254

AZD7254 是一种具有口服活性的 Smoothened (SMO) 抑制剂，对 sonic Hh protein (shh) 的 EC50 值为 1.0 nM。

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AZD7254 Chemical Structure

AZD7254 Chemical Structure

CAS No. : 1126366-28-6

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规格 是否有货
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AZD7254 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].

体内研究
(In Vivo)

AZD7254 (40 mg/kg; p.o.; twice daily for 10 days) exhibits 42% tumor growth inhibition in an HT29-MEF (murine embryonic fibroblast) co-implant xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

398.46

Formula

C24H22N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AZD7254 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD72541126366-28-6AZD 7254AZD-7254SmoSmoothenedColo205metastasized basal cell carcinomaantitumorsonic Hh proteinshhInhibitorinhibitorinhibit

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产品名称：
AZD7254
目录号：
HY-147744
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