2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Anti-infection
  3. Histamine Receptor SARS-CoV
  4. Azelastine

Azelastine  (Synonyms: 氮卓斯汀)

目录号: HY-B0462A
产品使用指南

摩尔计算器

Azelastine 属于抗组胺剂，是一种有效的选择性组胺 1 (H1) 拮抗剂。Azelastine 可用于过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Azelastine hydrochloride 通常具有更好的水溶性和稳定性。

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Azelastine Chemical Structure

Azelastine Chemical Structure

CAS No. : 58581-89-8

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Azelastine 的其他形式现货产品:

Other Forms of Azelastine:

Azelastine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].

IC50 & Target[1]

H1 Receptor

 

体外研究
(In Vitro)

Azelastine can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Azelastine 相关抗体:

Cell Proliferation Assay[5]

Cell Line: Human nasal epithelial cells (HNEpC)
Concentration: 100 μM, 400 μM
Incubation Time: 21 days
Result: Inhibited HNEpC growth.

Western Blot Analysis[5]

Cell Line: Human nasal epithelial cells (HNEpC)
Concentration: 100 μM
Incubation Time: 7 days
Result: Significantly up-regulated the H1R, M1R and M3R levels.
体内研究
(In Vivo)

Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model[2].
Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model[2].
Azelastine (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino Wistar rats (150-170 g), diabetic hyperlipidemic rats model[2]
Dosage: 4 mg/kg
Administration: Oral administration, daily, for 8 weeks
Result: Ameliorated aortic calcification and increased apolipoprotein A expression along with a decline in apolipoprotein B.
Clinical Trial
分子量

381.90

Formula

C22H24ClN3O
CAS 号
中文名称

氮卓斯汀
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Azelastine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azelastine58581-89-8氮卓斯汀Histamine ReceptorSARS-CoVSARS coronavirusantihistamineallergic rhinitisasthmaSARS-CoV-2Inhibitorinhibitorinhibit

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