Azt-pmap 

Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity^[1]. AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection^[2]. Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Azt-pmap shows anti-HIV-1 activities in infected C8166 and JM cells with EC₅₀s of 0.08 and0.32 μM, respectively. Azt-pmap displays toxicities in infected C8166 and JM cells with TC₅₀s of 500 μM, respectively. Azt-pmap inhibits virus replication^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

508.42

C₂₀H₂₅N₆O₈P

142629-81-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. McGuigan C, et al. Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT. Antiviral Res. 1992 Apr;17(4):311-21.  [Content Brief]

  [2]. Gray LR, et al. The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes. PLoS One. 2013 Apr 16;8(4):e62196.  [Content Brief]