2. Neuronal Signaling
  3. Amyloid-β
  4. Aβ aggregation-IN-1

Aβ aggregation-IN-1 (Compound 1b) 是一种淀粉样蛋白- β (amyloid-beta) 前体蛋白抑制剂。Aβ aggregation-IN-1 抑制纤维形成的 amyloid-beta 聚集和分解，IC50 值分别为 3.92 和 7.19 M。Aβ aggregation-IN-1 也抑制神经元细胞中的丙二醛的形成，增加细胞内还原谷胱甘肽 (GSH) 水平，抑制 caspase 3 。

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Aβ aggregation-IN-1 Chemical Structure

Aβ aggregation-IN-1 Chemical Structure

CAS No. : 352525-91-8

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Aβ aggregation-IN-1 相关抗体

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  • 生物活性

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生物活性

Aβ aggregation-IN-1 (Compound 1b) is an amyloid-beta precursor protein inhibitor. Aβ aggregation-IN-1 inhibits amyloid-beta aggregation and disaggregation of fibrillogenesis with IC50 values of 3.92 and 7.19 M, respectively. Aβ aggregation-IN-1 also inhibits malondialdehyde formation, augments the intracellular reduced glutathione (GSH) levals and inhibits caspase 3 in neuronal cells[1].

分子量

215.97

Formula

C9H8BF3O2
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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参考文献

Aβ aggregation-IN-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Aβ aggregation-IN-1352525-91-8Amyloid-ββ-amyloid peptideAβAbetaamyloid-betaaggregation and disaggregation of fibrillogenesiscaspase 3Inhibitorinhibitorinhibit

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