2. MAPK/ERK Pathway
  3. Raf
  4. B-Raf IN 18

B-Raf IN 18 (compound 26) 是一种 B-Raf 抑制剂，IC50 值为 3.8 nM。B-Raf IN 18 可用于抗癌相关研究。

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B-Raf IN 18 Chemical Structure

B-Raf IN 18 Chemical Structure

CAS No. : 1244644-50-5

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B-Raf IN 18 相关抗体

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BRaf c-Raf Raf

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

B-Raf IN 18 (compound 26) is a B-Raf inhibitor, with IC50 of 3.8 nM. B-Raf IN 18 can be used in anti-cancer related research[1].

IC50 & Target

B-RafV600E

3.8 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SK-MEL-28 EC50
11 nM
Compound: 24
Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr
Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr
[PMID: 21733693]
SK-MEL-28 IC50
23 nM
Compound: 1
Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as decrease in ERK phosphorylation incubated for 1 hr by immunoassay
Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as decrease in ERK phosphorylation incubated for 1 hr by immunoassay
[PMID: 24900673]
SK-MEL-28 IC50
48 nM
Compound: 1
Inhibition of B-Raf V600E mutant-driven SK-MEL-28 cell proliferation after 72 hrs by CellTiter-Glo luminescent assay
Inhibition of B-Raf V600E mutant-driven SK-MEL-28 cell proliferation after 72 hrs by CellTiter-Glo luminescent assay
[PMID: 24900673]
SK-MEL-28 EC50
8 nM
Compound: 24
Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant after 3 days by CellTiter-Glo assay
Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant after 3 days by CellTiter-Glo assay
[PMID: 21733693]
分子量

667.72

Formula

C31H28F3N7O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

B-Raf IN 18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

B-Raf IN 181244644-50-5RafRaf kinasesSulfonamideThiazoleInhibitorinhibitorinhibit

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