2. Membrane Transporter/Ion Channel
  3. BCRP
  4. BCRP-IN-1

BCRP-IN-1 (compound 48) 是乳腺癌耐药蛋白（BCRP）的有效抑制剂，在 Hoechst 33342 测定和脱镁叶绿酸 A 测定中的 IC50 分别为 2.92 μM 和 2.46 μM。

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BCRP-IN-1 Chemical Structure

BCRP-IN-1 Chemical Structure

CAS No. : 765899-28-3

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BCRP-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BCRP-IN-1 (compound 48) is a potent inhibitor of breast cancer resistance protein (BCRP), with IC50s of 2.92 μM and 2.46 μM in Hoechst 33342 assay and Pheophorbide A assay, respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDCK-II IC50
2.46 μM
Compound: 48
Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up to 120 mins by flow cytometry
Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up to 120 mins by flow cytometry
[PMID: 24184213]
MDCK-II IC50
2.92 μM
Compound: 48
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to 120 mins by fluorescence assay
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to 120 mins by fluorescence assay
[PMID: 24184213]
分子量

326.31

Formula

C16H14N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BCRP-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCRP-IN-1765899-28-3BCRPBreast cancer resistance proteinABCG2Cyclosporine AMRP1 cellsInhibitorinhibitorinhibit

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