2. GPCR/G Protein
  3. GCGR
  4. Beinaglutide

Beinaglutide  (Synonyms: GLP-1 (human))

目录号: HY-P3463 纯度: 99.74%
COA 产品使用指南

摩尔计算器

Beinaglutide 是一种人 GLP-1 多肽，与人 GLP-1(7-36) 具有几乎 100% 的同源性。Beinaglutide 在血糖控制、抑制食物摄入和胃排空和促进体重减轻方面表现出依赖于剂量的作用。Beinaglutide 具有研究超重/肥胖和非酒精性脂肪性肝炎 (NASH) 的潜力。

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Custom Peptide Synthesis

Beinaglutide Chemical Structure

Beinaglutide Chemical Structure

CAS No. : 123475-27-4

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规格 价格 是否有货 数量
1 mg ￥1600
In-stock
5 mg ￥3600
In-stock
10 mg ￥5800
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Beinaglutide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Beinaglutide is a human GLP-1 polypeptide that shares almost 100% homology with human GLP-1 (7–36). Beinaglutide displays does-dependent effects in glycemic control, inhibiting food intake and gastric empty and promoting weight loss. Beinaglutide has the potential for the research of overweight/obesity and nonalcoholic steatohepatitis (NASH)[1][2].

体外研究
(In Vitro)

Beinaglutide (100 nM；48 小时) 增加脂肪细胞中 Akt 磷酸化的表达，这些脂肪细胞被增强的胰岛素刺激[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Beinaglutide 相关抗体:

Western Blot Analysis[2]

Cell Line: 3T3L-1 cells
Concentration: 100 nM
Incubation Time: 48 h
Result: Increased the phosphorylation of Akt in the adipocytes that were potentiated insulin-stimulated.
体内研究
(In Vivo)

Beinaglutide (0.6、1.2、2.4 mg/kg；sc；每天 3 次，连续 7 天) 在小鼠中显示出控制血糖、抑制食物摄入和体重减轻的能力[1]。
Beinaglutide (150 μg/kg；sc；每日一次，持续 6 周) 增加脂肪细胞的胰岛素敏感性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type male C57BL/6 mice and Male Lepob/Lepob (ob/ob) mice (ob/ob-NASH mouse model was induced by GAN diet)[1]
Dosage: 0.6, 1.2, 2.4 mg/kg
Administration: S.c.; three times per day for 7 consecutive days
Result: Significantly reduced blood glucose with dosedependence in C57BL/6 and ob/ob mice, dose dependently inhibits food intake and gastric Emptying, and significantly reduced body weight, food intake with dose-dependence.
Animal Model: Eight-week-old male C57BL/6 mice[2]
Dosage: 150 µg/kg
Administration: S.c.; daily for 6 weeks
Result: Showed improved glucose tolerance and insulin sensitivity, decreased adipose tissue weight and adipocyte size and potentiated insulin sensitivity of adipocytes.
Clinical Trial
分子量

3298.61

Formula

C149H225N39O46
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 1.79 mg/mL (0.54 mM; ultrasonic and adjust pH to 5 with HCl; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Beinaglutide 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Beinaglutide123475-27-4GLP-1 (human)GCGRGlucagon Receptorglycemic controlfood intakegastric emptyweight lossNASHAktInhibitorinhibitorinhibit

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