2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Belantamab mafodotin

Belantamab mafodotin  (Synonyms: GSK2857916; Belantamab mafodotin-blm)

目录号: HY-P3239 纯度: 99.60%
COA

摩尔计算器

Belantamab mafodotin (GSK2857916) 是由人源化、聚焦化的抗 B 细胞成熟抗原 (BCMA) 单克隆抗体和 McMMAF 组成，具有抗骨髓瘤活性。

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Belantamab mafodotin Chemical Structure

Belantamab mafodotin Chemical Structure

CAS No. : 2050232-20-5

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规格 价格 是否有货 数量
1 mg ￥3600
In-stock
5 mg ￥9400
In-stock
10 mg   询价  
50 mg   询价  

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Belantamab mafodotin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. Belantamab mafodotin has anti-myeloma activity[1][2].

体外研究
(In Vitro)

Belantamab mafodotin 以 1 nM 的 Kd 值结合人 BCMA 蛋白[2]。
Belantamab mafodotin 以剂量和时间依赖性方式在多发性骨髓瘤细胞中诱导 G2/M 期阻滞[2]。
Belantamab mafodotin 显著促进人单核细胞来源的巨噬细胞对多发性骨髓瘤细胞的吞噬作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Belantamab mafodotin 相关抗体:
体内研究
(In Vivo)

与载体相比，Belantamab mafodotin 可显著提高患有 OPM2 肿瘤的小鼠的生存率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice harbouring OPM2 tumours[2]
Dosage: 4 mg/kg
Administration: IP, twice weekly for 4 doses
Result: Signifcantly improves survival compared to vehicle.
Clinical Trial
分子量

149000 (average)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Belantamab mafodotin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belantamab mafodotin2050232-20-5GSK2857916 Belantamab mafodotin-blmGSK 2857916GSK-2857916Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesmultiple myelomaDREAMM-2immunoconjugateB-cell maturation antigenanti-myelomaInhibitorinhibitorinhibit

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