2. Apoptosis
  3. TNF Receptor Apoptosis
  4. Benufutamab

Benufutamab  (Synonyms: GEN1029)

目录号: HY-P99470 纯度: 98.62%
COA

摩尔计算器

Benufutamab (GEN1029) 是一种死亡受体 5 (DR5) 特异性激动性抗体。Benufutamab 是 2 种非竞争性 DR5 特异性 IgG1 抗体的混合物，每种抗体的 Fc 结构域都有一个 E430G 突变。Benufutamab 具有抗肿瘤作用。

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CAS No. : 2109730-69-8

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规格 价格 是否有货 数量
1 mg ￥3200
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Benufutamab 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Chimeric; Humanized
体外研究
(In Vitro)

Benufutamab（GEN1029；HexaBody-DR5/DR5；20 µg/mL；24 小时）在多发性骨髓瘤 (MM) 细胞中诱导强效细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Benufutamab 相关抗体:

Cell Viability Assay[1]

Cell Line: Multiple myeloma (MM) cells
Concentration: 20 µg/mL
Incubation Time: 24 hours
Result: Induced potent cytotoxicity.
体内研究
(In Vivo)

Benufutamab（GEN1029；HexaBody-DR5/DR5；0.5-2 mg/kg；腹腔注射；每周一次；持续 9 周）在结直肠癌的 PDX 模型中显示出显着的抗肿瘤活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c athymic nude or NU/NU nude mice injected with colorectal cancer (CRC) cells[2]
Dosage: 0.5 mg/kg, or 2 mg/kg
Administration: i.p.; once a week; for 9 weeks
Result: Showed significant antitumor activity.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

贝奴妥单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Benufutamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benufutamab2109730-69-8GEN1029贝奴妥单抗GEN 1029GEN-1029TNF ReceptorApoptosisTumor Necrosis Factor ReceptorTNFRDR5E430Gantitumor effectsInhibitorinhibitorinhibit

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目录号：
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