2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Carboxylesterase Reactive Oxygen Species
  4. Benz-AP

Benz-AP 是一种有效的光敏剂 (photosensitizer)。Benz-AP 可以产生的单线态氧，与hCES2的活性呈负相关。Benz-AP 在低 hCES2 环境下对癌细胞显示出更高的光毒性。在双光子激发 (TPE) 下，Benz-AP 可产生 ROS 并杀死癌细胞和肿瘤球体。

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Benz-AP Chemical Structure

Benz-AP Chemical Structure

CAS No. : 2416220-53-4

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Benz-AP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 CC50
> 32 μM
Compound: Benz-AP
Dark toxicity against human A549 cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity against human A549 cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 35700557]
A549 CC50
4.4 μM
Compound: Benz-AP
Phototoxicity against human A549 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay
Phototoxicity against human A549 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay
[PMID: 35700557]
HepG2 CC50
> 32 μM
Compound: Benz-AP
Dark toxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 35700557]
HepG2 CC50
> 32 μM
Compound: Benz-AP
Phototoxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay
Phototoxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay
[PMID: 35700557]
MCF7 CC50
> 32 μM
Compound: Benz-AP
Dark toxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 35700557]
MCF7 CC50
1.6 μM
Compound: Benz-AP
Phototoxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay
Phototoxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay
[PMID: 35700557]
PANC-1 CC50
> 32 μM
Compound: Benz-AP
Dark toxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 35700557]
PANC-1 CC50
0.647 μM
Compound: Benz-AP
Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based ReadyProbes blue/
Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based ReadyProbes blue/
[PMID: 35700557]
PANC-1 CC50
0.647 μM
Compound: Benz-AP
Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based MTT assay
Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based MTT assay
[PMID: 35700557]
PANC-1 CC50
1.4 μM
Compound: Benz-AP
Phototoxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay
Phototoxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay
[PMID: 35700557]
分子量

299.32

Formula

C20H13NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Benz-AP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benz-AP2416220-53-4CarboxylesteraseReactive Oxygen SpeciesPANC-1 cellstumorhCES2Human carboxylesterase 2cancer cellsTPEphotocytotoxicityInhibitorinhibitorinhibit

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