2. Neuronal Signaling
  3. Tau Protein
  4. BF-170

BF-170 是一种选择性 tau 纤维结合剂，EC50 为 221 nM。BF-170 具有良好的血脑屏障穿透性， 在小鼠体内静脉注射 2 分钟后，脑组织中的浓度达到 9.1% ID/g (30 分钟后脑内清除率为 0.25% ID/g​)，可作为阿尔茨海默病 (AD) 中 tau 蛋白病理成像的探针。BF-170 在阿尔茨海默病早期阶段的研究中具有重要作用，有望用于 tau 相关神经退行性疾病的成像研究。

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BF-170 Chemical Structure

BF-170 Chemical Structure

CAS No. : 22191-97-5

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BF-170 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes). BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD). It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases[1].

分子量

220.27

Formula

C15H12N2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BF-170 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BF-17022191-97-5BF170BF 170Tau ProteinInhibitorinhibitorinhibit

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