2. Immunology/Inflammation
  3. Interleukin Related
  4. Bimekizumab

Bimekizumab  (Synonyms: 比美吉珠单抗; Anti-Human IL17A/IL-17F Recombinant Antibody)

目录号: HY-P99280 纯度: 95.00%
COA

摩尔计算器

Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) 是一种人源化单克隆抗体，可选择性中和 IL-17A 和 IL-17F。这两种细胞因子都能够促进成骨的人骨膜衍生细胞 (hPDC) 分化。因此，Bimekizumab 的应用，可以阻断炎症驱动的成骨分化。

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CAS No. : 1418205-77-2

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规格 价格 是否有货 数量
1 mg ￥4500
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5 mg ￥9500
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Bimekizumab 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) is a humanised monoclonal antibody, can selectively neutralises IL-17A and IL-17F. Both of them are pro-osteogenic with respect to human periosteum-derived cell (hPDC) differentiation. Thus Bimekizumab blocks the inflammation-driven osteogenic differentiation[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target[1]

IL-17A

 

IL-17F

 

体外研究
(In Vitro)

Bimekizumab (10 μg/mL; 1 h) results dual neutralisation of IL-17A and IL-17F, leads to osteocommitment of hPDCs by AS serum is suppressed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bimekizumab 相关抗体:
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

比美吉珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized IL-17A (136a.a)-17F Heterodimer Protein, Human can bind Bimekizumab. The EC50 for this effect is 16.18 ng/mL.
纯度 & 产品资料

纯度: 95.00%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Bimekizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bimekizumab1418205-77-2Anti-Human IL17A/IL-17F Recombinant Antibody比美吉珠单抗Interleukin RelatedILankylosing spondylitiscytokinesinflammationT cellsInhibitorinhibitorinhibit

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