释义：

The cancer immunity cycle (CIC) is comprised of a series of events that are required for immune-mediated control of tumor growth. This cycle can be divided into seven major steps, starting with the release of antigens from the cancer cell and ending with the killing of cancer cells. Firstly, the cycle is initiated by the release of cancer-associated antigens (CAAs) from dying cancer cells.  In mammals, these antigens are captured and processed by dendritic cells (DCs) and presented to naïve T-cells within tumor-draining lymph nodes.  The activated, cancer antigen-specific CD8+ T-cells mobilize to and infiltrate tumors, where they recognize and eliminate cancer cells via recognition of cognate peptide antigen bound to MHC class I molecules (pMHC) present on the cancer cell surface.  The subsequent release of additional CAAs initiates a new round of the CIC and amplifies the magnitude of the immune response with each subsequent round. Interference with one or more events of the CIC enables tumors to evade immune-mediated destruction.

癌症免疫周期 (CIC) 由免疫介导控制肿瘤生长所需的一系列事件组成。 这个循环可以分为七个主要步骤，从癌细胞释放抗原开始，到杀死癌细胞结束。 首先，这个循环是由垂死癌细胞释放的癌症相关抗原 (CAA) 启动的。 在哺乳动物中，这些抗原被树突状细胞 (DC) 捕获和处理，并呈递给肿瘤引流淋巴结内的幼稚 T 细胞。 活化的癌症抗原特异性 CD8+ T 细胞动员并浸润肿瘤，在那里它们通过识别与存在于癌细胞表面的 MHC I 类分子 (pMHC) 结合的同源肽抗原来识别和消除癌细胞。 随后释放额外的 CAA 会启动新一轮的 CIC，并在随后的每一轮中放大免疫反应的强度。 干扰 CIC 的一个或多个事件使肿瘤能够逃避免疫介导的破坏。