1. Biology Dictionary
  2. Dihydroorotate dehydrogenase (DHODH)

Dihydroorotate dehydrogenase (DHODH)二氢乳清酸脱氢酶

释义:

Dihydroorotate dehydrogenase (DHODH) is the key enzyme in de novo biosynthesis of pyrimidine in both prokaryotes and eukaryotes that provides nucleotides for RNA/DNA synthesis essential for proliferation. DHODH also is rate-limiting enzyme in biosynthesis of pyrimidone which catalyzes the oxidation of dihydro-orotate to orotate. DHODH paly a role in cancer cells proliferation.

二氢乳清酸脱氢酶 (DHODH) 是原核生物和真核生物中嘧啶从头生物合成的关键酶,它为 RNA/DNA 合成提供增殖所必需的核苷酸。DHODH 还是嘧啶酮生物合成中的限速酶,可催化二氢乳清酸氧化成乳清酸。DHODH 在癌细胞增殖中起作用。

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