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  3. Filamentous Phage Display

Filamentous Phage Display丝状噬菌体展示法

释义：

Filamentous phages (M13, f1, fd) have been extensively used to develop and implement the technology of phage display. Repertoires of relatively short peptides of random amino acid sequences or cDNA libraries have been constructed and searched successfully. Most experiments have taken advantage of the ability to assemble phages decorated with hybrid versions of the receptor protein pIII or of the major coat protein pVIII. Both systems allow the display of foreign peptides by fusion to the amino-terminus of the capsid protein but differ in the number of peptide copies that can be displayed on each phage particle. Display libraries of very diverse protein fragments have been constructed by fusing either genomic or cDNA fragments to gene III or gene VIII.

丝状噬菌体 (M13，f1，fd) 已广泛用于开发和实施噬菌体展示技术。已经构建并成功筛选了相对较短的随机氨基酸序列肽或 cDNA 文库。大多数实验已利用能够组装噬菌体的能力，这些噬菌体装饰有受体蛋白 pIII 或主要外壳蛋白 pVIII 的杂交版本。这两种系统通过将外源肽融合到外壳蛋白的氨基末端来展示外源肽，但它们在每个噬菌体颗粒上展示的肽拷贝数上有所不同。通过将基因 III 或基因 VIII 与基因组或 cDNA 片段融合，已经构建了多种多样的蛋白质片段展示文库。

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