2. GPCR/G Protein
  3. Bradykinin Receptor
  4. BKM-570

BKM-570 是一种具有抗癌作用的非肽缓激肽 (bradykinin) 拮抗剂。BKM-570 可用于肺癌、前列腺癌和卵巢癌的研究。

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BKM-570 Chemical Structure

BKM-570 Chemical Structure

CAS No. : 259885-54-6

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BKM-570 相关抗体

Top Publications Citing Use of Products

查看 Bradykinin Receptor 亚型特异性产品:

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C6 IC50
4 μM
Compound: BKM-570
Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
Cancer cell lines IC50
1.8 μM
Compound: BKM-570
Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
Granta IC50
63.3 μM
Compound: BKM-570
Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
HEK293 IC50
3.8 μM
Compound: BKM-570
Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
JeKo-1 IC50
49.3 μM
Compound: BKM-570
Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
U-373MG ATCC IC50
3.3 μM
Compound: BKM-570
Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 25012567]
分子量

698.55

Formula

C34H34Cl2F5N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BKM-570 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BKM-570259885-54-6BKM570BKM 570Bradykinin Receptorbradykinin antagonistlung cancerprostate cancer and ovarian cancerInhibitorinhibitorinhibit

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产品名称：
BKM-570
目录号：
HY-123560
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