2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. BmP02

BmP02 是一种选择性 Kv1.3 通道阻断剂和高选择性 Kv4.2 调节剂，可从中国蝎 (Buthus martensi Karsch) 毒液中分离出来。BmP02 还可延迟 HEK293T 细胞中 Kv4.2 的失活，EC50 值为约 850 nM。BmP02 抑制心室肌细胞中的瞬时外向钾电流 (Ito)。

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Custom Peptide Synthesis

BmP02 Chemical Structure

BmP02 Chemical Structure

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BmP02 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC50 value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells[1][2].

IC50 & Target

Kv1.3, Kv4.2[1]
分子量

2949.35

Formula

C115H182N36O41S7
Sequence

Val-Gly-Cys-Glu-Glu-Cys-Pro-Met-His-Cys-Lys-Gly-Lys-Asn-Ala-Lys-Pro-Thr-Cys-Asp-Asp-Gly-Val-Cys-Asn-Cys-Asn-Val (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26)
Sequence Shortening

VGCEECPMHCKGKNAKPTCDDGVCNCNV (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BmP02 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BmP02BmP 02BmP-02Potassium ChannelKcsAChinese scorpionButhus martensi KarschHEK293T cellstransient outward potassium currentsItoventricular muscle cellsInhibitorinhibitorinhibit

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