2. Immunology/Inflammation Apoptosis
  3. PD-1/PD-L1 Apoptosis
  4. BMS-202 hydrochloride

BMS-202 hydrochloride 是一种有效的非肽类 PD-1/PD-L 复合物抑制剂，其 IC50 为 18 nM，KD 为 8 μM。BMS-202 hydrochloride 与 PD-L1 直接结合并阻断人类 PD-1/PD-L 的相互作用。BMS-202 hydrochloride 具有抗肿瘤活性。

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BMS-202 hydrochloride Chemical Structure

BMS-202 hydrochloride Chemical Structure

CAS No. : 2089334-95-0

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BMS-202 hydrochloride 的其他形式现货产品:

Other Forms of BMS-202 hydrochloride:

BMS-202 hydrochloride 相关抗体

Top Publications Citing Use of Products

    BMS-202 hydrochloride purchased from MCE. Usage Cited in: Drug Dev Res. 2021 Jul 26.  [Abstract]

    Cultured Lβt2 cells are treated with 25 μM BMS-202 and collected at 24 h. the p-p38 MAPK, p38 MAPK, p-JNK, JNK, p-ERK, ERK, and α-tubulin protein levels are detected by Western Blotting.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    BMS-202 hydrochloride is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 hydrochloride binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 hydrochloride has antitumor activity[1][2].

    分子量

    455.98

    Formula

    C25H30ClN3O3
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    BMS-202 hydrochloride 相关分类

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    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BMS-2022089334-95-0BMS202BMS 202PD-1/PD-L1ApoptosisPD-1/Programmed death-ligand 1Thermal stabilizationnonpeptidicdimerichydrophobicantitumoranti-proliferationimmune-responseInhibitorinhibitorinhibit

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    产品名称：
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    目录号：
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