2. Anti-infection
  3. HIV
  4. BMS 488043

BMS 488043  (Synonyms: BMS 043)

目录号: HY-14135
产品使用指南

摩尔计算器

BMS 488043 (BMS 043) 是一种具有口服活性且耐受性良好的人类免疫缺陷病毒类型1 (HIV-1) 与 CD4+ 淋巴细胞结合的抑制剂。

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BMS 488043 Chemical Structure

BMS 488043 Chemical Structure

CAS No. : 452296-83-2

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BMS 488043 相关抗体

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS 488043 (BMS 043) is an orally active and well-tolerated inhibitor of the attachment of human immunodeficiency virus type 1 (HIV-1) to CD4+ lymphocytes[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa CC50
> 300 μM
Compound: 2, BMS-488043
Cytotoxicity against human HeLa cells expressing CD4 assessed as cell viability after 6 days by XTT assay
Cytotoxicity against human HeLa cells expressing CD4 assessed as cell viability after 6 days by XTT assay
[PMID: 23200252]
HeLa EC50
0.75 nM
Compound: 2, BMS-488043
Antiviral activity against HIV1 JRFL infected in human HeLa cells expressing CD4 and CCR5 assessed as inhibition of single-cycle viral replication by luciferase reporter gene assay
Antiviral activity against HIV1 JRFL infected in human HeLa cells expressing CD4 and CCR5 assessed as inhibition of single-cycle viral replication by luciferase reporter gene assay
[PMID: 23200252]
MT2 CC50
> 300 μM
Compound: 2; BMS-488043
Cytotoxicity against human MT2 cells assessed as decrease in cell viability after 3 days by XTT assay
Cytotoxicity against human MT2 cells assessed as decrease in cell viability after 3 days by XTT assay
[PMID: 29920093]
MT2 CC50
> 300 μM
Compound: 4, BMS-488043
Cytotoxicity against human MT2 cells after 3 days by XTT assay
Cytotoxicity against human MT2 cells after 3 days by XTT assay
[PMID: 19769332]
U-87MG ATCC CC50
> 40000 nM
Compound: 2, BMS-488043,BMS-043
Cytotoxicity against human U87 cells coexpressing CD4, CxCR4 receptors after 72 hrs
Cytotoxicity against human U87 cells coexpressing CD4, CxCR4 receptors after 72 hrs
[PMID: 19534463]
U-87MG ATCC IC50
26 nM
Compound: 27, BMS-488043
Antiviral activity against HIV1 pseudovirus in U87 cells expressing CD4 and CCR5 after 72 hrs by M33 pseudotyped assay
Antiviral activity against HIV1 pseudovirus in U87 cells expressing CD4 and CCR5 after 72 hrs by M33 pseudotyped assay
[PMID: 18052117]
分子量

422.43

Formula

C22H22N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS 488043 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS 488043452296-83-2BMS 043BMS488043BMS-488043BMS043BMS-043HIVHuman immunodeficiency viruswell-toleratedHIV-1CD4lymphocyteInhibitorinhibitorinhibit

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