2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. BMS-986308

BMS-986308 是一种选择性的，并具有口服活性的肾外髓质钾 (ROMK) 通道抑制剂。BMS-986308 对 ROMK 的选择性优于 hERG。BMS-986308 可用于心力衰竭研究。

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BMS-986308 Chemical Structure

BMS-986308 Chemical Structure

CAS No. : 2254333-97-4

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BMS-986308 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-986308 is a selective and orally active renal outer medullary potassium (ROMK) channel inhibitor. BMS-986308 is selective for ROMK over hERG. BMS-986308 can be used for heart failure research[1].

体内研究
(In Vivo)

BMS-986308（0.01-3 mg/kg；口服；一次）在容量负荷大鼠利尿模型中显示出疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (age: 8-12 weeks, 270-300 g)[1]
Dosage: 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg and 3 mg/kg
Administration: p.o; once (10% v/v DMAC, 40% v/v PEG400, 50% v/v of 30% w/v of HPβCD in 50 mM citrate buffer (pH 4.0))
Result: Led to a robust increase in diuresis.
分子量

443.50

Formula

C24H25N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS-986308 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-9863082254333-97-4BMS986308BMS 986308Potassium ChannelKcsAROMK Inhibitororally activeheart failureInhibitorinhibitorinhibit

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