2. Epigenetics Apoptosis
  3. Histone Demethylase Apoptosis
  4. Bomedemstat ditosylate

Bomedemstat ditosylate  (Synonyms: IMG-7289 ditosylate)

目录号: HY-109169A 纯度: 99.17%
COA 产品使用指南

摩尔计算器

Bomedemstat (IMG-7289) ditosylate 是一种具有口服活性和不可逆的 lysine-specific demethylase 1 (LSD1) 抑制剂。Bomedemstat ditosylate 可以增加 H3K4 和 H3K9 的甲基化，然后改变基因表达。Bomedemstat ditosylate 具有抗癌活性，可抑制癌细胞增殖并诱导细胞凋亡。

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Bomedemstat ditosylate Chemical Structure

Bomedemstat ditosylate Chemical Structure

CAS No. : 1990504-72-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥5512
In-stock
1 mg ￥1590
In-stock
5 mg ￥3500
In-stock
10 mg ￥5800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Bomedemstat ditosylate:

Bomedemstat ditosylate 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

查看所有亚型
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bomedemstat (IMG-7289) ditosylate is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat ditosylate can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat ditosylate shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis[1][2].

体外研究
(In Vitro)

Bomedemstat selectively inhibits proliferation and induces apoptosis of Jak2V617F cells by concomitantly increasing expression and methylation of p53[1].
Bomedemstat (50 nM-1 μM; 96 h) enhances survival, induces apoptosis via BCL-XL and PUMA in a TP53-dependent manner, and leads to cell cycle arrest[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bomedemstat ditosylate 相关抗体:

Apoptosis Analysis[1]

Cell Line: SET-2 cells
Concentration: 50 nM, 100 nM, and 1 μM
Incubation Time: 96 hours
Result: Decreased levels of the antiapoptotic protein BCL-XL and increased levels of the pro-apoptotic protein PUMA.
体内研究
(In Vivo)

Bomedemstat treatment (oral gavage; 45 mg/kg; once daily; 56 d) normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mx-Jak2V617F mice[1]
Dosage: 45 mg/kg
Administration: Oral gavage; 45 mg/kg; once daily; 56 days
Result: Reduced splenomegaly significantly with a few treated mice normalizing their spleen weight, the 56-day course led to partial restoration of lymph follicles and spleen architecture by histological examination.
Clinical Trial
分子量

864.02

Formula

C42H50FN7O8S2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (115.74 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1574 mL 5.7869 mL 11.5738 mL
5 mM 0.2315 mL 1.1574 mL 2.3148 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Bomedemstat ditosylate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1574 mL 5.7869 mL 11.5738 mL 28.9345 mL
5 mM 0.2315 mL 1.1574 mL 2.3148 mL 5.7869 mL
10 mM 0.1157 mL 0.5787 mL 1.1574 mL 2.8935 mL
15 mM 0.0772 mL 0.3858 mL 0.7716 mL 1.9290 mL
20 mM 0.0579 mL 0.2893 mL 0.5787 mL 1.4467 mL
25 mM 0.0463 mL 0.2315 mL 0.4630 mL 1.1574 mL
30 mM 0.0386 mL 0.1929 mL 0.3858 mL 0.9645 mL
40 mM 0.0289 mL 0.1447 mL 0.2893 mL 0.7234 mL
50 mM 0.0231 mL 0.1157 mL 0.2315 mL 0.5787 mL
60 mM 0.0193 mL 0.0964 mL 0.1929 mL 0.4822 mL
80 mM 0.0145 mL 0.0723 mL 0.1447 mL 0.3617 mL
100 mM 0.0116 mL 0.0579 mL 0.1157 mL 0.2893 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bomedemstat ditosylate1990504-72-7IMG-7289 ditosylateHistone DemethylaseApoptosisoral activitylysine-specific demethylase 1anti-cancer activityanti-proliferationinduce apoptosisSET-2Inhibitorinhibitorinhibit

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