2. Metabolic Enzyme/Protease Apoptosis Autophagy
  3. Phosphatase Apoptosis Autophagy
  4. Bonannione A

Bonannione A  (Synonyms: 6-香叶草基柚皮素; 6-Geranylnaringenin; Mimulone)

目录号: HY-124896
产品使用指南 技术支持

Bonannione A (6-Geranylnaringenin; Mimulone) 是一种异戊二烯类黄酮，一种口服有效的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，IC50 为 14 µM。Bonannione A 触发半胱天冬酶依赖性细胞凋亡。Bonannione A 通过 p53 介导的 AMPK/mTOR 通路诱导自噬。Bonannione A 显示出抗炎、抗自由基和抗癌活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Bonannione A Chemical Structure

Bonannione A Chemical Structure

CAS No. : 97126-57-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥5650
1 - 2 周
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

Bonannione A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BJ EC50
> 10 μM
Compound: 9
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
C3H 10T1/2 IC50
> 75 μM
Compound: 8
Cytotoxicity against mouse C3H10T1/2 cells after 24 hrs by fluorometric microculture assay
Cytotoxicity against mouse C3H10T1/2 cells after 24 hrs by fluorometric microculture assay
[PMID: 26178912]
CCRF-CEM EC50
11.6 μM
Compound: 9
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
HaCaT IC50
14.6 μM
Compound: 8
Inhibition of hedgehog signaling pathway in human HaCaT cells assessed as GLI1-mediated transcriptional activity after 12 hrs by luciferase assay
Inhibition of hedgehog signaling pathway in human HaCaT cells assessed as GLI1-mediated transcriptional activity after 12 hrs by luciferase assay
[PMID: 26178912]
HeLa EC50
> 10 μM
Compound: 9
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
MCF7 EC50
> 10 μM
Compound: 9
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
PANC-1 IC50
29.9 μM
Compound: 8
Cytotoxicity against Hh signaling abnormally activated human PANC1 cells after 24 hrs by fluorometric microculture assay
Cytotoxicity against Hh signaling abnormally activated human PANC1 cells after 24 hrs by fluorometric microculture assay
[PMID: 26178912]
RPMI-8226 EC50
> 10 μM
Compound: 9
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
THP-1 IC50
< 10 μM
Compound: 19
Cytotoxicity against human THP1 cells assessed as cell viability after 24 hrs by WST assay
Cytotoxicity against human THP1 cells assessed as cell viability after 24 hrs by WST assay
[PMID: 25735399]
THP-1 EC50
> 10 μM
Compound: 9
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
[PMID: 20192247]
U-266 EC50
> 10 μM
Compound: 9
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
体外研究
(In Vitro)

6-香叶草基柚皮素 (0-80 µM; 12, 24 小时) 在癌细胞系中以剂量和时间依赖性方式显着抑制细胞增殖[2]。
6-香叶草基柚皮素 (0-60 µM; 24 小时) 在 A549 细胞中触发半胱天冬酶依赖性细胞凋亡。6-香叶草基柚皮素增加凋亡亚 G1 期细胞的积累和 G2/M 期细胞的数量[2]。
6-香叶草基柚皮素 (60 µM; 24 小时) 在 A549 细胞中触发自噬而不损害自噬通量[2]。
6-香叶草基柚皮素 (60 µM; 24 小时) 显着降低 p53 和磷酸化 mTOR 的水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bonannione A 相关抗体:

Cell Proliferation Assay[2]

Cell Line: Human lung cancer A549, breast cancer MCF-7, colon cancer HCT116 and osteosarcoma U2OS cells
Concentration: 20, 40, 60, 80 µM
Incubation Time: 12, 24 h
Result: Significantly inhibited cell proliferation in a dose- and time-dependent way in these cancer cell lines.

Apoptosis Analysis[2]

Cell Line: A549 cells
Concentration: 0-60 µM
Incubation Time: 24 h
Result: Annexin V/PI-positive cells were markedly increased in a dose- and time-dependent way.
Induced apoptosis through caspase-3 activation and PARP cleavage.

Cell Cycle Analysis[2]

Cell Line: A549 cells
Concentration: 0-60 µM
Incubation Time: 24 h
Result: Increased accumulation of cells at the apoptotic sub-G1 phase in a dose-dependent manner.
The number of cells at G2/M phase also increased in a dose-dependent manner.

Cell Autophagy Assay[2]

Cell Line: A549 cells
Concentration: 60 µM
Incubation Time: 24 h
Result: Remarkably increased ATG7 and LC3-II protein levels in a dose-dependent way, but Beclin-1 level was slightly augmented.

Western Blot Analysis[2]

Cell Line: A549 cells
Concentration: 60 µM
Incubation Time: 0-24 h
Result: Remarkably decreased the levels of p53 and phospho-mTOR. Significantly increased whereas the levels of phospho-AMPK and phospho-Acetyl-CoA Carboxylase (ACC), an AMPK substrate.
体内研究
(In Vivo)

6-香叶草基柚皮素 (25 mg/kg; 灌胃; DSS 前 48 和 24 小时，随后每 24 小时一次; 持续 5 天) 改善结肠炎的症状并延迟其发作[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (180-220 g)[3]
Dosage: 25 mg/kg
Administration: Gavage; 48 and 24 h prior to DSS (10% (w/v)) and every 24 h on the following days; for 5days
Result: Ameliorated the symptoms of colitis and delayed their onset.
Showed the low DAI on the last day of the experiment.
分子量

408.49

Formula

C25H28O5
CAS 号
中文名称

6-香叶草基柚皮素
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bonannione A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bonannione A97126-57-36-Geranylnaringenin Mimulone6-香叶草基柚皮素PhosphataseApoptosisAutophagyprenylflavonoidprotein tyrosine phosphatase 1BPTP1Bcaspase p53 AMPK/mTORanti-inflammatoryantiradicalanti-cancerA549LC3-ILC3-IIInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Bonannione A
目录号：
HY-124896
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z