2. Apoptosis Autophagy MAPK/ERK Pathway Stem Cell/Wnt
  3. Apoptosis Autophagy JNK ERK
  4. Bozepinib

Bozepinib 是一种 PKR (RNA-dependent protein kinase) 激活剂，并能有效抑制 HER-2 信号通路以及 JNK 和 ERK 激酶。Bozepinib 可诱导 PKR 介导的细胞凋亡，并与 IFNα 协同触发细胞凋亡、自噬和衰老。Bozepinib 还在异种移植裸鼠中显示出体内抗肿瘤和抗转移功效。

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Bozepinib Chemical Structure

Bozepinib Chemical Structure

CAS No. : 1207993-83-6

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Bozepinib 相关抗体

Top Publications Citing Use of Products

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bozepinib is a PKR (RNA-dependent protein kinase) activator and potently inhibits the HER-2 signaling pathway as well as JNK and ERK kinases. Bozepinib induces PKR-mediated apoptosis and synergizes with IFNα to trigger apoptosis, autophagy and senescence. Bozepinib also demonstrates in vivo antitumor and antimetastatic efficacy in xenografted nude mice[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF-10A IC50
1.825 μM
Compound: (RS)-14
Cytotoxicity against human MCF10A cells after 3 days by SRB assay
Cytotoxicity against human MCF10A cells after 3 days by SRB assay
[PMID: 21126804]
MCF7 IC50
0.355 μM
Compound: (RS)-14
Cytotoxicity against human MCF7 cells expressing wild type p53 and ras mutant after 3 days by SRB assay
Cytotoxicity against human MCF7 cells expressing wild type p53 and ras mutant after 3 days by SRB assay
[PMID: 21126804]
MDA-MB-231 IC50
0.166 μM
Compound: (RS)-14
Cytotoxicity against human MDA-MB-231 cells expressing high level of p53 after 3 days by SRB assay
Cytotoxicity against human MDA-MB-231 cells expressing high level of p53 after 3 days by SRB assay
[PMID: 21126804]
分子量

521.33

Formula

C20H14Cl2N6O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bozepinib 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bozepinib1207993-83-6ApoptosisAutophagyJNKERKc-Jun N-terminal kinaseExtracellular signal regulated kinasesHER-2tumorcancerapoptosisautophagysenescenceInhibitorinhibitorinhibit

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