Bradykinin acetate 

Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin acetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain^{[1][2][3][4][5]}.

Bradykinin acetate 是一种有效的血管扩张肽，通过刺激特定的内皮 B2 受体发挥其血管扩张作用，从而导致前列环素、NO 和 EDHF 的释放^[1]。
Bradykinin acetate 参与多种癌症的进展。Bradykinin acetate 处理促进结直肠癌细胞的侵袭和迁移。Bradykinin acetate 处理可刺激 ERK1/2 激活和 IL-6 产生^[2]。
外源性 bradykinin acetate 以剂量依赖性方式显著抑制 LPS 诱导的 TF 在 mRNA 和蛋白水平的表达。NO 合酶拮抗剂 L-NAME 和 PI3K 抑制剂 LY294002 显著消除了 bradykinin acetate 对组织因子表达的抑制作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

将 1 μM bradykinin acetate 应用于卵巢会导致心率和平均动脉压显著降低。在迷走神经切断的动物中，将 1 μM bradykinin acetate 应用于卵巢会产生心动过缓和低血压，类似于迷走神经支配完好时诱发的反应^[4]。
血管 bradykinin acetate 可以改善重症急性胰腺炎大鼠的胰腺微循环和血液流变学。48 h，血管 bradykinin acetate 处理组胰腺微循环血流量和流速逐渐升高^[5]。
Bradykinin acetate 给药诱导的 PI3K/Akt 信号通路激活降低了 GSK-3β 和 MAPK 的活性，并降低了细胞核中的 NF-x03BA；B 水平，从而抑制了 TF 表达。与此相一致的是，C57/BL6小鼠腹腔注射 Bradykinin 也能抑制结扎下腔静脉引起的血栓形成^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1016.21 (free base)

C₅₀H₇₃N₁₅O₁₁.xC₂H₄O₂

6846-03-3

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

RPPGFSPFR

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hornig B, et al. Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors inhumans. Circulation. 1997 Mar 4;95(5):1115-8.  [Content Brief]

  [2]. Wang G, et al. Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. Oncol Rep. 2014 Oct;32(4):1709-14.  [Content Brief]

  [3]. Dong R, et al. Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway. Cell Physiol Biochem. 2015;37(4):1592-606.  [Content Brief]

  [4]. Uchida S, et al. Afferent fibers involved in the bradykinin-induced cardiovascular reflexes from the ovary in rats. Auton Neurosci. 2015 Dec;193:57-62.  [Content Brief]

  [5]. Liu LT, et al. Effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. Eur Rev Med Pharmacol Sci. 2015;19(14):2646-50.  [Content Brief]