2. MAPK/ERK Pathway
  3. Raf
  4. BRAF V600E/CRAF-IN-2

BRAF V600E/CRAF-IN-2 (Compound 9c) 是一种有效的 BRAF V600E/CRAF 抑制剂，具有 IC 50s 分别为 0.888 和 0.229 μM。BRAF V600E/CRAF-IN-2 在 HCT-116 结肠癌细胞的 G0/G1 期触发细胞凋亡和细胞周期停滞。BRAF V600E/CRAF-IN-2具有研究癌症疾病的潜力。

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BRAF V600E/CRAF-IN-2 Chemical Structure

BRAF V600E/CRAF-IN-2 Chemical Structure

CAS No. : 2499499-62-4

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BRAF V600E/CRAF-IN-2 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].

分子量

549.59

Formula

C30H30F3N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRAF V600E/CRAF-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRAF V600E/CRAF-IN-22499499-62-4RafRaf kinasesapoptosiscell cycle arrestG0/G1 phasecancerInhibitorinhibitorinhibit

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