2. Apoptosis
  3. Apoptosis
  4. BRD0476

BRD0476 是一种胰腺 β 细胞凋亡抑制剂，EC50 值为0.78μM，最大抑制活性为99%。BRD0476 可用于糖尿病的相关研究。

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BRD0476 Chemical Structure

BRD0476 Chemical Structure

CAS No. : 1314958-91-2

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BRD0476 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRD0476 is an inhibitor of pancreatic β-cell apoptosis with an EC50 value of 0.78 μM and a maximal inhibitory activity of 99%. BRD0476 can be used in diabetes-related research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
INS-1E EC50
0.78 μM
Compound: 13, BRD0476
Inhibition of IL-1beta, IFN-gamma and TNF-alpha-induced apoptosis of rat INS-1E cells assessed as restoring cell viability after 48 hrs by luciferase based CellTiter-Glo assay
Inhibition of IL-1beta, IFN-gamma and TNF-alpha-induced apoptosis of rat INS-1E cells assessed as restoring cell viability after 48 hrs by luciferase based CellTiter-Glo assay
[PMID: 21927648]
INS-1E IC50
1.66 μM
Compound: 1, BRD0476
Cytoprotective activity in rat INS-1E cells assessed as suppression of cytokine-induced caspase-3/7 activation after 48 hrs by luminescence assay
Cytoprotective activity in rat INS-1E cells assessed as suppression of cytokine-induced caspase-3/7 activation after 48 hrs by luminescence assay
[PMID: 23617753]
体外研究
(In Vitro)

在细胞因子存在下，BRD0476 以剂量依赖性方式降低半胱天冬酶-3活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRD0476 相关抗体:
分子量

674.76

Formula

C35H38N4O8S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRD0476 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD04761314958-91-2ML187BRD 0476BRD-0476ML 187ML-187ApoptosisApoptosis Inhibitorβ-cell apoptosisdiabetesInhibitorinhibitorinhibit

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目录号：
HY-120711
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