2. Epigenetics Apoptosis
  3. Epigenetic Reader Domain c-Myc
  4. BRD4 Inhibitor-40

BRD4 Inhibitor-40 (Compound 23) 是 BRD 的抑制剂，可抑制 BRD4-BD1、BRD4-BD2、BRD2-BD1 和 BRD2-BD2，IC50 分别为 16.1、142.18、29.35 和 302.35 nM。BRD4 Inhibitor-40 可调节 c-Myc 和 p21 的表达，在 G1 期阻滞细胞周期，抑制 Pkd1 缺陷 (PN) 肾囊性上皮细胞，并在 Madin-Darby 犬肾和胚胎肾囊泡模型中阻断肾囊肿形成。BRD4 Inhibitor-40 在小鼠模型中表现出肾囊肿抑制活性。

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BRD4 Inhibitor-40 Chemical Structure

BRD4 Inhibitor-40 Chemical Structure

CAS No. : 2994635-04-8

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BRD4 Inhibitor-40 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRD4 Inhibitor-40 (Compound 23) is the inhibitor for BRD that inhibits BRD4-BD1, BRD4-BD2, BRD2-BD1 and BRD2-BD2 with IC50s of 16.1, 142.18, 29.35 and 302.35 nM, respectively. BRD4 Inhibitor-40 modulates the expression of c-Myc and p21, arrests cell cycle at G1 phase, inhibits Pkd1-null (PN) renal cystic epithelial cells, and blocks the renal cysts formation in Madin-Darby canine kidney and embryonic kidney vesicle models. BRD4 Inhibitor-40 exhibits renal cysts inhibitory activity in mouse models[1].

IC50 & Target

BRD4 BD1

16.1 nM (IC50)

BRD2 BD1

29.35 nM (IC50)

BRD4 BD2

142.18 nM (IC50)

BRD2 BD2

302.35 nM (IC50)

分子量

484.60

Formula

C27H32N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRD4 Inhibitor-40 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 Inhibitor-402994635-04-8Epigenetic Reader Domainc-MycMycInhibitorinhibitorinhibit

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