2. Immunology/Inflammation
  3. NO Synthase
  4. Britannilactone diacetate

Britannilactone diacetate  (Synonyms: 1,6-O,O-Diacetylbritannilactone; Di-O-acetylbritannilactone)

目录号: HY-N4190
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Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) 具有潜在的 NO 抑制作用。 Britannilactone diacetate 对 BV-2 小胶质细胞中 LPS 诱导的 NO 产生具有活性，EC50 值为 6.3 μM。 Britannilactone diacetate 可透过血脑屏障，具有良好的吸收、分布、代谢、排泄和毒性 (ADMET) 特性。

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Britannilactone diacetate Chemical Structure

Britannilactone diacetate Chemical Structure

CAS No. : 1286694-67-4

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Britannilactone diacetate 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BV-2 EC50
6.3 μM
Compound: 2; OABL
Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay
[PMID: 34315042]
HCT-116 IC50
10.1 μM
Compound: OABL
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
10.1039/C4MD00209A
HeLa IC50
11.2 μM
Compound: OABL
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
10.1039/C4MD00209A
SGC-7901 IC50
15.9 μM
Compound: OABL
Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
10.1039/C4MD00209A
分子量

350.41

Formula

C19H26O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Britannilactone diacetate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Britannilactone diacetate1286694-67-41,6-O,O-Diacetylbritannilactone Di-O-acetylbritannilactoneNO SynthaseNitric oxide synthasesNOSMacrophageRAW264.7 cellsNitric oxideNOInhibitorinhibitorinhibit

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