BRL-15572 hydrochloride 

BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses^[1].

BRL-15572 has 60-fold higher affinity for h5-HT1D (pK_i=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells^[1].
BRL-15572 (0.1 nM-10 μM) stimulates [³⁵S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test^[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

443.41

C₂₅H₂₈Cl₂N₂O

1173022-77-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Price GW, et, al. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep; 356(3): 312-20.  [Content Brief]

  [2]. Geovanna NQ, et, al. Antinociceptive effect of (-)-epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr; 29(2 and 3-Spec Issue): 270-279.  [Content Brief]

  [3]. Hagan JJ, et, al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23; 331(2-3): 169-74.  [Content Brief]