2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Membrane Transporter/Ion Channel
  3. Histamine Receptor mAChR Potassium Channel Sodium Channel Calcium Channel
  4. Brompheniramine maleate (Standard)

Brompheniramine maleate (Standard)  (Synonyms: 马来酸溴苯那敏 (Standard))

目录号: HY-B0480R 纯度: ≥98%
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Brompheniramine (maleate) (Standard) 是 Brompheniramine (maleate) 的分析标准品。本产品用于研究及分析应用。Brompheniramine ((±)-Brompheniramine) maleate 是一种有效的且具有口服活性的丙胺类抗组胺剂。Brompheniramine maleate 是一种选择性组胺 H1 受体 (histamine H1 receptor) 拮抗剂，Kd 为 6.06 nM。Brompheniramine maleate 可阻断 hERG 通道 (hERG channels)、钙离子通道 (calcium channels) 和钠离子通道 (sodium channels)，IC50 分别为 0.90 μM、16.12 μM 和 21.26 μM。Brompheniramine maleate 具有抗胆碱能、抗抑郁以及麻醉作用，可用于过敏性鼻炎和缓解疼痛的研究。

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Brompheniramine maleate (Standard) Chemical Structure

Brompheniramine maleate (Standard) Chemical Structure

CAS No. : 980-71-2

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生物活性

Brompheniramine (maleate) (Standard) is the analytical standard of Brompheniramine (maleate). This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research.

分子量

435.31

Formula

C20H23BrN2O4
CAS 号
中文名称

马来酸溴苯那敏 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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Keywords:

Brompheniramine maleate (Standard)980-71-2马来酸溴苯那敏 (Standard)Histamine ReceptormAChRPotassium ChannelSodium ChannelCalcium ChannelMuscarinic acetylcholine receptorKcsANa channelsNa+ channelsCa2+ channelsCa channelsanticholinergicantidepressantsedativecommon coldallergic rhinitisantihistamineInhibitorinhibitorinhibit

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