2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. BTK-IN-18

BTK-IN-18 是一种有效的、可逆的 BTK 抑制剂，IC50 为 0.002 µM。BTK-IN-18 在体内抑制 CD69 和 CD86。

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BTK-IN-18 Chemical Structure

BTK-IN-18 Chemical Structure

CAS No. : 1374239-71-0

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BTK-IN-18 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo[1].

体内研究
(In Vivo)

BTK-IN-18 (化合物 41; 10, 25, 45 mg/kg; 腹腔给药; 单剂量) 对 CD69 和 CD86 产生强烈的剂量依赖性抑制[1]。
BTK-IN-18 (静脉给药; 1 mg/kg) 在大鼠中的 T1/2 为 5.3 小时，CL 为 19 mL/min/kg，Vss 为 1.3 L/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 10, 25, 45 mg/kg
Administration: IP; single dose
Result: Caused robust dose-dependent inhibition of both CD69 and CD86 (74.8 %, 50.3 %, and 21.5 % respectively).
Animal Model:
Dosage:
Administration:
Result: Pharmacokinetic Parameters of BTK-IN-18 in rats[1].
IV (1 mg/kg) PO (5 mg/kg)
Tmax (h) 1.6
Cmax (h∗mg/mL) 321
AUCinfi (h∗mg/mL) 1013 1421
t1/2 (ng/mL) 5.3
CL (mL/min/kg) 19
Vss (L/kg) 1.3
F (%) 23%
分子量

433.33

Formula

C20H22Cl2N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BTK-IN-18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK-IN-181374239-71-0BtkBruton tyrosine kinaseBTKCD69CD86Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-152201
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