2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. BTK-IN-23

BTK-IN-23 是一种 BTK 抑制剂 (IC50: 12.8 nM)。BTK-IN-23 还抑制 BLX 和 BMX，IC50 分别为 35.6 和 5.7 nM。与 Ibrutinib (HY-10997) 相比，BTK-IN-23 显示出更高的激酶选择性。

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BTK-IN-23 Chemical Structure

BTK-IN-23 Chemical Structure

CAS No. : 2573048-11-8

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BTK-IN-23 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BTK-IN-23 is a BTK inhibitor (IC50: 12.8 nM). BTK-IN-23 also inhibits BLX and BMX with IC50s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1].

体外研究
(In Vitro)

BTK-IN-23 (化合物 3) 抑制 Jeko-1 细胞中的 BTK 自磷酸化，IC50 为 314 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BTK-IN-23 相关抗体:

Western Blot Analysis[1]

Cell Line: Jeko-1 cell
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 2 h
Result: Inhibited BTK autophosphorylation.
分子量

468.55

Formula

C27H28N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BTK-IN-23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK-IN-232573048-11-8BtkBruton tyrosine kinaseJeko-1IbrutinibBLXBMXInhibitorinhibitorinhibit

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产品名称：
BTK-IN-23
目录号：
HY-148594
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