2. Stem Cell/Wnt TGF-beta/Smad
  3. PKA
  4. Bucladesine

Bucladesine  (Synonyms: 布拉地新; Dibutyryl cAMP; DBcAMP)

目录号: HY-B0764B
产品使用指南 技术支持

Bucladesine (DBcAMP) 是一种膜渗透性选择性激活剂，能够激活环磷酸腺苷 (cAMP) 依赖性蛋白激酶A (PKA)。Bucladesine 的主要调节机制涉及 cAMP/PKA 信号通路。当 Bucladesine 激活 PKA 时，它可以促进多种细胞过程，包括神经发育、生长和可塑性。cAMP/PKA 信号通路在长时程增强 (LTP) 和长时程抑制 (LTD) 的表达，以及海马长期记忆的形成中也扮演关键角色。Bucladesine 可用于记忆形成和神经可塑性的研究。

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Bucladesine Chemical Structure

Bucladesine Chemical Structure

CAS No. : 362-74-3

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Bucladesine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bucladesine (DBcAMP) is a membrane permeable selective activator that activates cyclic adenosine phosphate dependent protein kinase A (PKA). The main regulatory mechanism of Bucladesine involves the cAMP/PKA signaling pathway. When Bucladesine activates PKA, it can promote a variety of cellular processes, including neurodevelopment, growth and plasticity. In particular, the cAMP/PKA signaling pathway plays a key role in the expression of long-term enhancement (LTP) and long-term inhibition (LTD), as well as in the formation of long-term memory in the hippocampus. Bucladesine can be used to study memory formation and neuroplasticity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
28.9 μM
Compound: dbcAMP
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
[PMID: 11000020]
分子量

469.39

Formula

C18H24N5O8P
CAS 号
中文名称

布拉地新； 二丁酰环磷腺苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bucladesine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bucladesine362-74-3Dibutyryl cAMP DBcAMP布拉地新 二丁酰环磷腺苷PKAProtein kinase AcAMPNeuroplasticityMemory FormationNeurobiologyInhibitorinhibitorinhibit

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