1. GPCR/G Protein TGF-beta/Smad Stem Cell/Wnt
  2. Prostaglandin Receptor TGF-beta/Smad
  3. Butaprost free acid

Butaprost free acid 是一种选择性前列腺素 E 受体 (EP2) 激动剂,对鼠类 EP2 受体的 EC50 值为 33 nM,Ki 值为 2.4 μM。Butaprost free acid 对鼠类 EP1,EP3 和 EP4 受体的活性较低。Butaprost free acid 通过阻碍 TGF-β/Smad2 信号传导来减轻纤维化。

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Butaprost free acid Chemical Structure

Butaprost free acid Chemical Structure

CAS No. : 215168-33-5

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规格 价格 是否有货 数量
500 μg ¥1818
3 - 4 周

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Other Forms of Butaprost free acid:

查看 Prostaglandin Receptor 亚型特异性产品:

  • 生物活性

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  • 参考文献

生物活性

Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling[1][2][3].

体外研究
(In Vitro)

Butaprost (1-100 nM;0.5-24 小时) free acid 诱导 hEP2-HEK293/EBNA 细胞中 Nur77 mRNA 表达,上调大约五倍,且呈剂量和时间依赖性。Butaprost free acid 通过 PKC 通路上调 Nur77 基因表达[1]
Butaprost (50 μM;24 小时) free acid 降低 TGF-β 诱导的纤连蛋白 (FN) 表达、Smad2 磷酸化和上皮-间充质 Madin-Darby 犬肾 (MDCK) 细胞的转变[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK 293/EBNA cells stably expressing the human EP2 receptor (hEP2-HEK 293/EBNA cells).
Concentration: 1 nM, 10 nM, 100 nM
Incubation Time: 0.5 hours, 1 hours, 6 hours, 24 hours
Result: Induced about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells.
体内研究
(In Vivo)

Butaprost (1-4 mg/kg;腹膜内注射;每天两次;持续 7 天) free acid 处理可减轻接受单侧输尿管梗阻手术的小鼠纤维化的发展,如 α-平滑肌基因和蛋白表达的减少所示肌动蛋白、纤连蛋白和胶原蛋白 1A1[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (8 weeks of age; 21 g) bearing unilateral ureteral obstruction surgery[2].
Dosage: 1 mg/kg, 2 mg/kg, 4 mg/kg
Administration: Intraperitoneal injection; twice daily; for 7 days
Result: Attenuated the development of fibrosis in mice that underwent unilateral ureteral obstruction surgery.
分子量

394.54

Formula

C23H38O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Butaprost free acid
目录号:
HY-120973
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