2. Protein Tyrosine Kinase/RTK Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. c-Met/HGFR HDAC Apoptosis
  4. c-Met/HDAC-IN-3

c-Met/HDAC-IN-3 (Compound 15f) 是一种 c-Met 和 HDAC 抑制剂，对 c-Met 和 HDAC1 的 IC50 分别为 12.50 nM 和 26.97 nM。 c-Met/HDAC-IN-3 诱导凋亡（apoptosis），导致细胞周期阻滞在 G2/M 期。

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c-Met/HDAC-IN-3 Chemical Structure

c-Met/HDAC-IN-3 Chemical Structure

CAS No. : 2439175-23-0

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c-Met/HDAC-IN-3 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

c-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase[1].

IC50 & Target

HDAC1

26.97 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1.08 μM
Compound: 74
Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 34052677]
HCT-116 IC50
0.54 nM
Compound: 74
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34052677]
体外研究
(In Vitro)

c-Met/HDAC-IN-3 (Compound 15f) (0-20 μM, 72 h) shows antiproliferative activities against HCT-116, MCF-7 and A549 cells[1].
c-Met/HDAC-IN-3 (0-5 μM, 48 h) induces apoptosis and arrests cell cycle at G2/M phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

c-Met/HDAC-IN-3 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HCT-116, MCF-7 and A549
Concentration: 0-20 µM
Incubation Time: 72 h
Result: Showed antiproliferative activities with IC50 values of 0.54 ± 0.05, 0.28 ± 0.02 and 1.08 ± 0.44 μM against HCT-116, MCF-7 and A549 cells.

Apoptosis Analysis[1]

Cell Line: HCT-116
Concentration: 0.2, 1.0 and 5.0 µM
Incubation Time: 48 h
Result: Resulted in 6.97%, 7.08% and 13.21% cells apoptosis at 0.2, 1.0 and 5.0 µM, respectively.

Cell Cycle Analysis[1]

Cell Line: HCT-116
Concentration: 0.2, 1.0 and 5.0 µM
Incubation Time: 48 h
Result: Showed an obvious increase in the proportion of cells in G2/M phase in a dose-dependent manner.
分子量

630.66

Formula

C34H35FN4O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

c-Met/HDAC-IN-3 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

c-Met/HDAC-IN-32439175-23-0c-Met/HGFRHDACApoptosisHistone deacetylasesHCT-116MCF-7A549Inhibitorinhibitorinhibit

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