2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. c-Met-IN-1

c-met-IN-1 (compound 16) 是一种高效选择性的 c-Met 抑制剂，IC50 值为 1.1 nM，具有抗肿瘤活性。

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c-Met-IN-1 Chemical Structure

c-Met-IN-1 Chemical Structure

CAS No. : 2084836-84-8

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c-Met-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1].

IC50 & Target

IC50: 1.1 nM (c-Met)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.07 μM
Compound: 16
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 28011202]
HT-29 IC50
0.08 μM
Compound: 16
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 28011202]
MKN-45 IC50
0.22 μM
Compound: 16
Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay
Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay
[PMID: 28011202]
体外研究
(In Vitro)

c-met-IN-1 (compound 16) exhibits high selectivity and remarkable cytotoxicity against HT-29, MKN-45 and A549 cells with IC50 values of 0.08 μM, 0.22 μM and 0.07 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

c-Met-IN-1 相关抗体:
分子量

640.70

Formula

C35H37FN6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

c-Met-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met-IN-12084836-84-8c-Met/HGFRInhibitorinhibitorinhibit

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