2. Metabolic Enzyme/Protease Apoptosis Stem Cell/Wnt MAPK/ERK Pathway
  3. Phosphatase Apoptosis ERK p38 MAPK JNK
  4. Cantharidic acid

Cantharidic acid  (Synonyms: 斑蝥酸)

目录号: HY-137135
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Cantharidic acid 是蛋白磷酸酶 2 (PP2A) 和蛋白磷酸酶 1 (PP1) 的选择性抑制剂。Cantharidic acid 通过上调 ERK1/2、p38 和 JNK1/2 通路抑制细胞活力，在亚 G1 期阻滞细胞周期，诱导 NPC-39 和 HONE-1 细胞凋亡 (apoptosis)。

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Cantharidic acid Chemical Structure

Cantharidic acid Chemical Structure

CAS No. : 28874-45-5

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Other Forms of Cantharidic acid:

Cantharidic acid 相关抗体

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ERK ERK1 ERK2 ERK5 ERK8

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
218.5 μM
Compound: 4
Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33454654]
HL-60 IC50
103.2 μM
Compound: 4
Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33454654]
KB 3-1 IC50
79.2 μM
Compound: 4
Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33454654]
分子量

214.22

Formula

C10H14O5
CAS 号
中文名称

斑蝥酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cantharidic acid 相关分类

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cantharidic acid28874-45-5斑蝥酸PhosphataseApoptosisERKp38 MAPKJNKExtracellular signal regulated kinasesc-Jun N-terminal kinaseNPC-39NPC-BMHONE-1nasopharyngeal carcinomaNPCInhibitorinhibitorinhibit

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