Canthin-6-one

目录号: HY-N3536 纯度: 99.92%: FAQs
Data Sheet SDS COA 产品使用指南技术支持

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Canthin-6-one Chemical Structure

CAS No. : 479-43-6

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规格	价格	是否有货
1 mg	￥2080	In-stock
5 mg	￥5200	In-stock
10 mg	现货	询价
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100 mg		询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Canthin-6-one displays a wide range of biological activities, such as antimycobacterial activity^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	ED₅₀	3.6 μg/mL Compound: 5	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 14575431]
ADR5000 cell line	IC₅₀	10.52 μM Compound: 25	Cytotoxicity against human multidrug-resistant CEM/ADR5000 cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay Cytotoxicity against human multidrug-resistant CEM/ADR5000 cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay	[PMID: 34332400]
C6	EC₅₀	15 μM Compound: 1	Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
Calu-3	CC₅₀	> 100 μM Compound: Table 1, R11C2	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
CCRF-CEM	IC₅₀	15.82 μM Compound: 25	Cytotoxicity against human drug sensitive CCRF-CEM cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay Cytotoxicity against human drug sensitive CCRF-CEM cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay	[PMID: 34332400]
DU-145	IC₅₀	9.43 μg/mL Compound: 25	Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay	[PMID: 34332400]
HCC1395	IC₅₀	8.12 μg/mL Compound: 25	Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay	[PMID: 34332400]
HCT-8	CC₅₀	42.41 μM Compound: Table 1, R11C2	Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
HeLa	EC₅₀	15 μM Compound: 1	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
HepG2	CC₅₀	85.65 μM Compound: Table 1, R11C2	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
HT-29	EC₅₀	15 μM Compound: 1	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
Jurkat	EC₅₀	15 μM Compound: 1	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
Keratinocyte	IC₅₀	1.11 μg/mL Compound: 25	Cytotoxicity against guinea pig ear keratinocytes using [3H]thymidine by liquid scintillation counting analysis Cytotoxicity against guinea pig ear keratinocytes using [3H]thymidine by liquid scintillation counting analysis	[PMID: 34332400]
MCF7	ED₅₀	7.3 μg/mL Compound: 5	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 14575431]
MRC5	CC₅₀	91.16 μM Compound: Table 1, R11C2	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
NHDF	EC₅₀	115 μM Compound: 1	Toxicity against human NHDF assessed as reduction in cell viability incubated for 3 days by MTT assay Toxicity against human NHDF assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 25379743]
NIH3T3	EC₅₀	15 μM Compound: 1	Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
PC-3	EC₅₀	15 μM Compound: 1	Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days	[PMID: 25379743]
Vero	CC₅₀	> 100 μM Compound: Table 1, R11C2	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]

分子量

220.23

Formula

C₁₄H₈N₂O

CAS 号

479-43-6

性状

固体

颜色

White to light yellow

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 25 mg/mL (113.52 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.5407 mL	22.7035 mL	45.4071 mL
5 mM	0.9081 mL	4.5407 mL	9.0814 mL
10 mM	0.4541 mL	2.2704 mL	4.5407 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.92%

选择批次：

Data Sheet (603 KB) SDS (252 KB)

COA (206 KB) HNMR (318 KB) CNMR (302 KB) RP-HPLC (188 KB) MS (188 KB)

产品使用指南 (1538 KB)

参考文献

[1]. O'Donnell G, Gibbons S. Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum. Phytother Res. 2007;21(7):653-657. [Content Brief]

Canthin-6-one 相关分类

Inflammation/Immunology

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.5407 mL	22.7035 mL	45.4071 mL	113.5177 mL
	5 mM	0.9081 mL	4.5407 mL	9.0814 mL	22.7035 mL
	10 mM	0.4541 mL	2.2704 mL	4.5407 mL	11.3518 mL
	15 mM	0.3027 mL	1.5136 mL	3.0271 mL	7.5678 mL
	20 mM	0.2270 mL	1.1352 mL	2.2704 mL	5.6759 mL
	25 mM	0.1816 mL	0.9081 mL	1.8163 mL	4.5407 mL
	30 mM	0.1514 mL	0.7568 mL	1.5136 mL	3.7839 mL
	40 mM	0.1135 mL	0.5676 mL	1.1352 mL	2.8379 mL
	50 mM	0.0908 mL	0.4541 mL	0.9081 mL	2.2704 mL
	60 mM	0.0757 mL	0.3784 mL	0.7568 mL	1.8920 mL
	80 mM	0.0568 mL	0.2838 mL	0.5676 mL	1.4190 mL
	100 mM	0.0454 mL	0.2270 mL	0.4541 mL	1.1352 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canthin-6-one479-43-6BacterialInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Canthin-6-one

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