2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage Cytoskeleton
  3. Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin
  4. Cantuzumab mertansine

Cantuzumab mertansine  (Synonyms: 莫坎妥珠单抗; SB-408075; huC242-DM1)

目录号: HY-P99492 纯度: 96.02%
COA

摩尔计算器

Cantuzumab mertansine (SB-408075; huC242-DM1) 是一种 ADC，是强效美登素衍生物 (DM1; HY-19792) 和针对 CanAg 的人源化单克隆抗体 (huC242) 的免疫偶联物。Cantuzumab mertansine 对结肠癌细胞具有细胞毒性，并且对一系列 CanAg 阳性人肿瘤异种移植物具有广泛的抗肿瘤活性。

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Cantuzumab mertansine Chemical Structure

Cantuzumab mertansine Chemical Structure

CAS No. : 400010-39-1

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Cantuzumab mertansine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2].

体外研究
(In Vitro)

Cantuzumab mertansine (SB-408075; huC242-DM1; 0-100 μM; 24 小时) 对抗原阳性 COLO 205 细胞系具有选择性细胞毒活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cantuzumab mertansine 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Antigen-positive COLO 205 cell line and the antigen-negative A-375 melanoma cell line
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Had cytotoxic activity on COLO 205 cells with an IC50 value of 0.032 nM (23.5 pg/ml).
Had 1100-fold less cytotoxic activity for the antigen-negative A-375 cells (IC50=36 nM; 26.5 ng/ml).
体内研究
(In Vivo)

Cantuzumab mertansine (SB-408075; huC242-DM1; 300 μg/kg/天; 持续 5 天) 使携带 COLO 205 结肠癌人异种移植物的小鼠完全消退和治愈[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CB-17 SCID mice, 6-7 weeks of age bearing COLO 205 human colon tumor xenografts[1]
Dosage: 300 μg/kg
Administration: Daily for 5 days
Result: Completely eliminated any measurable tumors within 2 weeks of the initiation of therapy, and all eight animals were tumor-free for 200 days (duration of the experiment).
分子量

150000 (average)

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

莫坎妥珠单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cantuzumab mertansine 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Cantuzumab mertansine400010-39-1SB-408075 huC242-DM1莫坎妥珠单抗SB408075SB 408075Antibody-Drug Conjugates (ADCs)Microtubule/TubulinAntibody-Drug ConjugatesADCimmunoconjugatemaytansinehuC242CanAgcolon cancerColo 205HT-29LoVoInhibitorinhibitorinhibit

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