2. GPCR/G Protein
  3. GHSR
  4. Capromorelin

Capromorelin  (Synonyms: CP 424391)

目录号: HY-15242
产品使用指南

摩尔计算器

Capromorelin (CP 424391) 是一种吡唑啉-哌啶二肽。Capromorelin 是一种具有口服活性的 生长激素分泌剂 (GHS) (hGHS-R1a Ki=7 nM，大鼠垂体细胞 EC50=3 nM)。

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Capromorelin Chemical Structure

Capromorelin Chemical Structure

CAS No. : 193273-66-4

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Capromorelin 的其他形式现货产品:

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Other Forms of Capromorelin:

Capromorelin 相关抗体

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GHSR1a

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Capromorelin (CP 424391) is a pyrazolinone-piperidine dipeptide. Capromorelin is an orally active and potent growth hormone secretagogue (GHS) (hGHS-R1a Ki=7 nM, rat pituicyte EC50=3 nM)[1].

IC50 & Target

GHSR1a

7 nM (Ki)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Pituitary gland cell EC50
3 nM
Compound: CP 424 391-18
Stimulation of growth hormone secretion in Wistar rat pituitary cells measured after 15 mins
Stimulation of growth hormone secretion in Wistar rat pituitary cells measured after 15 mins
[PMID: 35344905]
体内研究
(In Vivo)

在麻醉大鼠模型中，Capromorelin 可增加血浆GH水平，且ED50值小于 0.05 mg/kg iv[1]。
Capromorelin 在啮齿类动物模型中表现出增强肠道吸收的特性，并表现出优异的药代动力学特性，包括两种动物的高生物利用度 [F(大鼠)=65%，F(狗)=44%][1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

505.61

Formula

C28H35N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Capromorelin 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Capromorelin193273-66-4CP 424391CP424391CP-424391GHSRGrowth hormone secretagogue receptorGhrelin receptorrat pituitary cellsInhibitorinhibitorinhibit

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